SLAC Reprint SLAC-REPRINT-2014-010
SLAC Release Date: March 3, 2014
Ground State Destabilization by Anionic Nucleophiles Contributes to the Activity of Phosphoryl Transfer Enzymes
Andrews, L.
DOI: 10.1371/journal.pbio.1001599

Enzymes stabilize transition states of reactions while limiting binding to ground states, as is generally required for any catalyst. Alkaline Phosphatase (AP) and other nonspecific phosphatases are some of Nature's most impressive catalysts, achieving preferential transition state over ground state stabilization of more than 1022-fold while utilizing interactions ... Show Full Abstract
DOI: 10.1371/journal.pbio.1001599

Enzymes stabilize transition states of reactions while limiting binding to ground states, as is generally required for any catalyst. Alkaline Phosphatase (AP) and other nonspecific phosphatases are some of Nature's most impressive catalysts, achieving preferential transition state over ground state stabilization of more than 1022-fold while utilizing interactions with only the five atoms attached to the transferred phosphorus. Show Partial Abstract
  • Interest Categories: Bio-life Sciences
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